5/1/2023 0 Comments Ts matilde queensSignificant differences between the ↑LFTs-group and the normal-LFTs-group were found for age (P=0.01), HRT duration (P=0.004), Tot-Chol (P=0.009) and LDL-Chol (P=0.011). The most frequently abnormality was a raised GGT in 91% of cases ↑ALT and ALP were found in 40%. Liver enzymes were elevated in 35 (34%) patients, with a duration of 7y (☖.2SD) and age at the first finding of ↑LFTs 34y (☑2.9SD). Ascending aorta diameters, measured with echocardiography and cardiac MR, were analyzed. LFTs were collected, along with karyoptype, anthropometric, metabolic and TS-related diseases and treatments. Methods: We reviewed our adult TS cohort. The aim of this study was to analyse the association between ↑LFTs and a comprehensive panel of TS-related conditions, focusing on metabolic and cardiovascular diseases in order to further elucidate the pathophysiological mechanisms underlying this. The cause and clinical significance are unclear. It suggests that ↑LFTs may be commoner in TS patients with 45,X0, and/or hypertension, hyperlipidaemia and autoimmunity.Īims: Elevated liver function tests (↑LFTs) are frequent in Turners Syndrome (TS). Liver biopsy was performed in three patients: one normal, one NAFLD and one showed chronic hepatitis.Ĭonclusions: This study confirms that the prevalence of ↑LFTs increases with age, that an adequate oestrogen milieu may be protective, and HRT does not need to be discontinued in the presence of ↑LFTs. Two patients had a normal Fibroscan and one a normal MRCP. The frequency of hypertension, dyslipidaemia and thyroid autoimmunity was higher in the ↑LFTs-group (35% vs 14%, 23% vs 7% and 27% vs 17%, respectively).Ībdominal-ultrasonography was normal in ten cases, suggestive of NAFLD (non-alcoholic-fatty-liver-disease) in four and in one showed nodularity and hepatosplenomegaly. 48% of patients with ↑LFTs had a karyotype 45,X0 vs 32.5% in the normal-LFs-group. Age was significantly higher in the ↑LFTs-group (42.5 year☑3.1 S.D. The prevalence of spontaneous menstruation was higher in the normal-LFTs-group. There was no association between ↑LFTs and anthropometric values (height/weight/BMI), diabetes, HbA1c, renal or cardiac malformations, and either GH or oestrogen therapy. In the normal-LFTs-group no past history of ↑LFTs was noted. Hepatitis serology and autoimmune-markers were negative, bilirubin was normal and no reported alcohol consumption in all. Results: Twenty six women (38%) had one or more liver enzymes persistently raised (duration 5.6 years☓.8 S.D.), with the most frequently elevated enzyme being GGT in 92% of cases, and ALT, ALP and AST in 77, 69 and 38%, respectively. Objectives: To study the prevalence of ↑LFTs and their relationship with karyotype, anthropometric, metabolic and TS-related conditions: 68 TS women, average age 39 years (range 18≦1 years), were reviewed. Their pathogenesis and clinical significance is unclear. Introduction: Elevated liver function tests (↑LFTs) are frequent in Turners syndrome (TS), with a prevalence between 20 and 80%, and increases with age.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |